Findings could lead to development of pre-clinical stage therapeutics
By Jason Clement
For decades researchers have known that Alzheimer鈥檚 disease (AD) causes the atrophy of a system of neurons and synapses highly involved in memory, learning and attention, which is highly dependent on a molecule known as nerve growth factor (NGF). The disease causes dysregulation of NGF鈥檚 metabolism, leading to the loss of the synapses and neurons that depend on it, akin to plants being deprived of light.