韩国裸舞

Ashkan Ertefaie, PhD

Associate Professor
Department of Biostatistics, Epidemiology & Informatics
Division of Biostatistics | UPenn

WHEN:聽Wednesday, February 12, 2025, from 3:30 to 4:30 p.m.
WHERE:聽Hybrid | 2001 韩国裸舞 College Avenue, Room 1140;
NOTE:聽Ashkan Ertefaie will be presenting from Philadelphia

Abstract

Real-world clinical decision making is a complex process that involves balancing the risks and benefits of treatments. Quality-adjusted lifetime is a composite outcome that combines patient quantity and quality of life, making it an attractive outcome in clinical research. We propose methods for constructing optimal treatment length strategies to maximize this outcome. Existing methods for estimating optimal treatment strategies for survival outcomes cannot be applied to a quality-adjusted lifetime due to induced informative censoring. We propose a weighted estimating equation that adjusts for both confounding and informative censoring. We also propose a nonparametric estimator of the mean counterfactual quality-adjusted lifetime survival curve under a given treatment length strategy, where the weights are estimated using an undersmoothed sieve-based estimator. We show that the estimator is asymptotically linear and provide a data-dependent undersmoothing criterion. We apply our method to obtain the optimal time for percutaneous endoscopic gastrostomy insertion in patients with amyotrophic lateral sclerosis.

Speaker Bio

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