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Sebastian Wachsmann Hogiu

Academic title(s): 

Professor

Undergraduate Program Director

Sebastian Wachsmann Hogiu
Contact Information
Email address: 
sebastian.wachsmannhogiu [at] mcgill.ca
Phone: 
514.398.1520
Office: 
McConnell Engineering Building, Room 362
Degree(s): 

BSc: Bucharest University, Physics, Biophysics

PhD: Humboldt University, Berlin, Experimental Physics,

PostDoc: Carnegie Mellon University, Pittsburgh, Chemical Physics

Previous Appointments: Carnegie Mellon University, Pittsburgh; Cedars Sinai Medical Center, Los Angeles; University of California Davis, Davis; Intellectual Ventures / Global Good, Seattle

Areas of interest: 
  • Biosensors
  • Biomimetics
  • Point of need and wearable technologies
  • Quantum Biology
Courses: 
  • BIEN 210: Electrical and Optical Properties of Optical Systems
  • BIEN 390: Bioengineering Laboratory
  • BIEN 560: Design of Biosensors
Selected publications: 
  1. Adam Melnyk, Lena Kozarov, Sebastian Wachsmann-Hogiu, “ A deconvolution approach to modelling surges in COVID-19 cases and deaths”, Scientific Reports, 13 (1), 2361.
  2. Meruyert Imanbekova, Ayse Mine Saridag, Mehmet Kahraman, Juanjuan Liu, Humeyra Caglayan, and Sebastian Wachsmann-Hogiu, “Complementary Metal Oxide Semiconductor Based Sensing Platform for Trapping, Imaging, and Chemical Characterization of Biological Samples”. ACS Applied Optical Materials, 2022, .
  3. Juanjuan Liu, Sebastian Wachsmann-Hogiu, “Progress and Challenges of Point of Need Photonic Biosensors for the Diagnosis of COVIDS-19 Infections and Immunity”, Biosensors, 2022,
  4. Meruyert Imanbekova, Sorina Suarasan, Yao Lu, Sarah Jurchuk, Sebastian Wachsmann-Hogiu, “Recent advances in label-free characterization of extracellular vesicles”, Nanophotonics, 04/2022.
  5. Reza Abbasi, Juanjuan Liu, Sorina Suarasan, Sebastian Wachsmann-Hogiu, “SE-ECL on a CMOS: a miniaturized electrochemiluminescence system”, Lab on a Chip, 02/2022.
  6. Juanjuan Liu, Roozbeh Siavash Moakhar, Sara Mahshid, Fartash Vasefi, Sebastian Wachsmann-Hogiu, “Multimodal electrochemical and SERS platform for chlorphenapyr detection”, Applied Surface Science, 2021, Vol 566, pp. 150617.
  7. Meruyert Imanbekova, Sorina Suarasan, Tatu Rojalin, Rachel Mizenko, Silvia Hilt, Meghna Mathur, Paula Lepine, Michael Nicouleau, Nguyen-Vi Mohamed, Thomas Durcan, Randy Carney, John Voss, Sebastian Wachsmann-Hogiu, “Identification of amyloid beta in small extracellular vesicles via Raman spectroscopy”, Nanoscale Advances, 2021, 3, 4119-4132.
  8. Juanjuan Liu, Mahsa Jalali, Sara Mahshid, Sebastian Wachsmann-Hogiu, "Are plasmonic optical biosensors ready for use in point-of-need applications?", Analyst, 2020, Vol. 145, pp. 364-384.
  9. Sorina Suarasan, Juanjuan Liu, Meruyert Imanbekova, Tatu Rojalin, Silvia Hilt, John C Voss, Sebastian Wachsmann-Hogiu, "Superhydrophobic bowl-like SERS substrates patterned from CMOS sensors for extracellular vesicle characterization", Journal of Materials Chemistry B, 2020, Vol. 8, pp. 8845-8852.
  10. Juanjuan Liu, Roozbeh Siavash Moakhar, Ayyappasamy Sudalaiyadum Perumal, Horia Nicolae Roman, Sara Mahshid, Sebastian Wachsmann-Hogiu, "A AgNP-deposited commercial electrochemistry test strip as a platform for urea detection", Scientific Reports, 2020, Vol 10, pp. 1-11.
  11. Meruyert Imanbekova, Ayyappasamy Sudalaiyadum Perumal, Sara Kheireddine, Dan V Nicolau, Sebastian Wachsmann-Hogiu, “Lensless, reflection-based dark-field microscopy (RDFM) on a CMOS chip", Biomedical Optics Express, 2020, Vol. 11, pp. 4942-4959.
  12. Sebastian Wachsmann-Hogiu, Zachary J Smith, Mehmet Kahraman, “”, Frontiers in Chemistry, 2019, 7, pp.865
  13. Sara Kheireddine, Zachary J Smith, Dan V Nicolau, Sebastian Wachsmann-Hogiu, “”, Biomedical optics express, 2019, 10(9), pp. 4369-4380.
  14. Sara Kheireddine, Ayyappasamy Sudalaiyadum Perumal, Zachary J. Smith, Dan V. Nicolau, and Sebastian Wachsmann-Hogiu, Dual-Phone Illumination-Imaging System for High Resolution and Large Field of View Multi-Modal Microscopy, Lab on a Chip, 2019.
  15. Korkmaz, M. Kenton, G. Aksin, M. Kahraman, S. Wachsmann-Hogiu, “Inexpensive and flexible substrates on adhesive tape based on biosilica plasmonic nanocomposites”, ACS Applied Nano Materials, 2018/8/17.
  16. Rebeca Ferraz de Menezes, Catherine Malinda Harvey, Marleny Elizabeth Márquez de Martínez Gerbi, Zachary J Smith, Dan Smith, Juan C Ivaldi, Alton Phillips, James W Chan, Sebastian Wachsmann-Hogiu, “Fs-laser ablation of teeth is temperature limited and provides information about the ablated components” Journal of Biophotonics 05/2017;, DOI:10.1002/jbio.201700042
  17. Mehmet Kahraman, Emma R. Mullen, Aysun Korkmaz, Sebastian Wachsmann-Hogiu, “Fundamentals and applications of SERS-based bioanalytical sensing”, Nanophotonics 01/2017; 6(5)., DOI:10.1515/nanoph-2016-0174.
  18. Ruby K. Gill, Zachary J. Smith, Changwon Lee, and Sebastian Wachsmann-Hogiu, “The effects of laser repetition rate on femtosecond laser ablation of dry bone: a thermal and LIBS study”, Journal of Biophotonics, 9 (1-2), 171-180, 2016.
  19. Tingjuan Gao, Zachary Smith, Tzu-yin Lin, Danielle Carrade Holt, Stephen M Lane, Dennis L Matthews, Denis M Dwyre, James Hood, Sebastian Wachsmann-Hogiu, ””, Analytical chemistry 87 (23), 11854-11862, 2015.
  20. Ruby K Gill, Zachary J Smith, Ripul R Panchal, John W Bishop, Regina Gandour-Edwards, Sebastian Wachsmann-Hogiu, , Biomedical Optics Express, 6 (12), 4850-4858, 2015.
  21. Kaiqin Chu, Zachary J. Smith, Sebastian Wachsmann-Hogiu, “Developing an inexpensive blood imaging system: where are we now?”, Expert Review of Medical Devices. 12(5), 613-627, 2015.
  22. Changwon Lee, Randy P. Carney, Sidhartha Hazari, Zachary Smith, Alisha Knudson, Christopher S. Robertson, Kit S. Lam and Sebastian Wachsmann-Hogiu*, “3D plasmonic nanobowl platform for the study of exosomes in solution”, Nanoscale, 2015, DOI: 10.1039/C5NR01333J.
  23. Zachary J Smith, Changwon Lee, Tatu Rojalin, Randy P Carney, Sidhartha Hazari, Alisha Knudson, Kit Lam, Heikki Saari, Elisa Lazaro Ibañez, Tapani Viitala, Timo Laaksonen, Marjo Yliperttula, Sebastian Wachsmann-Hogiu, , Journal of Extracellular Vesicles, 5, 2015
  24. Changwon Lee, Christopher S. Robertson, An H. Nguyen, Mehmet Kahraman, Sebastian Wachsmann-Hogiu, “Thickness of a metallic film, in addition to its roughness, plays a significant role in SERS activity”, online, Scientific Reports 5, 2015
  25. Ralph Green, Sebastian Wachsmann-Hogiu, “Development, history, and future of automated cell counters”, Clinics in Laboratory Medicine, 35, 2015, pp. 1-10.
  26. Mehmet Kahraman, Sebastian Wachsmann-Hogiu, “Label-Free and Direct Protein Detection on 3D Plasmonic Nanovoid Structures using Surface-Enhanced Raman Scattering”, Analytica Chimica Acta, 856, 2015, pp. 74-81.
  27. R. K. Gill, F. Knorr, Z. J. Smith, M. Kahraman, D. Madsen, D. S. Larsen, S. Wachsmann-Hogiu, “Characterization of Femtosecond Laser Induced Breakdown Spectroscopy (fsLIBS) and Applications for Biological Samples”, Applied Spectroscopy, Vol. 68, 9, 2014, pp. 949-54
  28. Z. J. Smith, T. Gao, K. Chu, S. M. Lane, D. L. Matthews, D. M. Dwyre, J. Hood, K. Tatsukawa, L. Heifetz, and S. Wachsmann-Hogiu, “Single-step preparation and image-based counting of minute volumes of human blood”, Lab on a Chip, 14 (16), 2014, pp. 3029-3036.
  29. M. A. S. de Oliveira, Z. J. Smith, F. Knorr, R. E. de Araujo, and S.Wachsmann-Hogiu, “Long Term Raman Spectral Study of Power-Dependent Photodamage in Red Blood Cells”, Applied Physics Letters, 104, 2014, 103702.
  30. M. Kahraman, P. Daggumati, O. Kurtulus, E. Seker, S. Wachsmann-Hogiu, “Fabrication and Characterization of Flexible and Tunable Plasmonic Nanostructures”, Scientific Reports 3, 2013: 3396 | DOI: 10.1038/srep03396.
  31. T. Zhang, S. Osborn, C. Brandow, D. Dwyre, R. Green, S.M. Lane, S. Wachsmann-Hogiu, “Structured Illumination-Based Super-Resolution Optical Microscopy for Hemato- and Cyto-Pathology Applications”, Analytical Cellular Pathology, 36 (1) 2013, pp. 27-35.
  32. M. Kahraman , B.N. Balz and S. Wachsmann-Hogiu, “Hydrophobicity-driven self-assembly of protein and silver nanoparticles for protein detection using surface-enhanced Raman scattering”, Analyst, 138 (10), 2013, pp. 2906-2913.
  33. Z. J. Smith, T. R. Huser, S. Wachsmann-Hogiu, “Raman scattering in pathology”, Analytical Cellular Pathology, 2012, 35 (3), pp. 145-163.
  34. Z. J. Smith, C.-W. Chang, L. S. Lawson, S. M. Lane, S. Wachsmann-Hogiu, “Precise Monitoring of Chemical Changes through Localization Analysis of Dynamic Spectra (LADS),” Applied Spectroscopy, 67(2), 2013, pp. 187-195.
  35. Z. J. Smith*, K.Q Chu, S. Wachsmann-Hogiu, “Nanometer-Scale Sizing Accuracy of Particle Suspensions on an Unmodified Cell Phone Using Elastic Light Scattering”, PLoSONE, Oct. 2nd 2012, 7(10), e46030.
  36. Z. J. Smith, S. Strombom, S. Wachsmann-Hogiu, “Multivariate optical computing using a digital micromirror device for fluorescence and Raman spectroscopy”, Optics Express, 2011, Vol. 19, Issue 18, pp. 16950-16962.
  37. Z. J. Smith, K. Chu, A. R. Espenson, M. Rahimzadeh, A. Gryshuk, M. Molinaro, D. M. Dwyre, S. M. Lane, D. Matthews, S. Wachsmann-Hogiu, “Cell-phone-based platform for biomedical device development and education applications”, PLoSONE, 2011, 6(3): e17150.
  38. C. V. Pagba, S. M. Lane, S. Wachsmann-Hogiu, “Conformational changes in quadrulpex oligonucleotide structures probed by Raman spectroscopy”, Biomedical Optics Express, Vol. 2, Issue 2, 2011, pp. 207-217.
  39. F. Knorr, Z. J. Smith, S. Wachsmann-Hogiu, “Development of a time-gated system for Raman spectroscopy of biological samples”, Optics Express, Vol. 18, No. 19, 2010, pp. 20049-20058.
  40. C. V. Pagba, S. M. Lane, H. Cho, S. Wachsmann-Hogiu, “Direct detection of aptamer-thrombin binding via surface-enhanced Raman spectroscopy”, J. Biomed. Opt., Vol. 15 (4), 2010, 047006.
  41. C. V. Pagba, S. M. Lane, S. Wachsmann-Hogiu, “Raman and SERS studies of the 15-mer DNA Thrombin Binding Aptamer”, Journal of Raman Spectroscopy, Vol. 41, Issue 3, 2010, pp. 241-247.
  42. S. Wachsmann-Hogiu, T. Weeks, T. Huser, “Chemical analysis in vivo and in vitro Raman spectroscopy – from single cells to humans”, Curr. Opinions in Biotech., Vol. 20, 2009, pp. 63-73
  43. S. Wachsmann-Hogiu, L. A. Peteanu, L. A. Liu, D. J. Yaron, J. Wildeman, “The Effects of Structural and Micro- Environmental Disorder on the Electronic Properties of MEH-PPV and Related Oligomers”, J. Phys. Chem. B, vol. 107, 2003, pp. 5133-5143.
  44. S. Wachsmann-Hogiu, W. Werncke, J. Dreyer, A. I. Vodchits, K.-W. Brzezinka, “Ultrafast intramolecular electron transfer studied by stationary vibrational and time-resolved resonance Raman spectroscopy combined with ab initio calculations”, Recent Res. Devel. Chem. Physics, Vol. 2, 2001, pp. 83-106.
  45. S. Hogiu, J. Dreyer, M. Pfeiffer, K.-W. Brzezinka, W. Werncke, “Vibrational analysis and excited-state geometric changes of betaine-30 derived from Raman and infrared spectra combined with ab initio calculations”, J. Raman Spectrosc., Vol. 31, Issue 8/9, 2000, pp. 797-803.
  46. S. Hogiu, W. Werncke, M. Pfeiffer, J. Dreyer, T. Elsaesser, “Mode-specific vibrational excitation and energy redistribution after ultrafast intramolecular electron transfer”, J. Chem. Phys., Vol. 113, Issue 4, 2000, pp. 1587-1594.
  47. S. Hogiu, W. Werncke, M. Pfeiffer, T. Elsaesser, “Mode specific vibrational kinetics after intramolecular electron transfer studied by anti-Stokes Raman spectroscopy”, Chem. Phys. Lett., Vol. 312, Issue 5-6, Oct. 1999, pp. 407-414.
  48. S. Hogiu, W. Werncke, M. Pfeiffer, A. Lau, “Evidence of strong vibronic coupling in the first excited singlet state of diphenylhexatriene by picosecond CARS spectroscopy”, Chem. Phys. Lett., Vol. 303, Issue 1-2, 2 April 1999, pp. 218-222.
  49. S. Hogiu, W. Werncke, M. Pfeiffer, A. Lau, T. Steinke, “Picosecond time-resolved CARS spectroscopy of a mixed excited singlet state of diphenylhexatriene”, Chem. Phys. Lett., Vol. 287, Issue 1-2, 24 April 1998, pp. 8-16.
  50. M.L. Pascu, B. Carstocea, G. Popescu, O. Gafencu, S. Apostol, N. Moise, M. Roman, S. Hogiu, “Imaging corneal cells using low power beams”, Lasers in Medical Science, Vol. 13, Issue 2, 1998, pp. 148-154.
  51. S. Hogiu, M. Enescu, M.L. Pascu, “Dynamic and thermodynamic effects of glycerol on bovine serum albumin in aqueous solution: a tryptophan phosphorescence study”, J. of Photochem.Photobiol. B: Biology, Vol. 40, Issue 1, Aug. 1997, pp. 55-60.
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